cbd oil and keppra

Cannabis oil for epilepsy – what you need to know


Professor of Pharmacology, University of Reading

Disclosure statement

I have been approached by Dragonfly Biosciences who produce and market cannabidiol (CBD) to sit on their Advisory Panel. I do not receive funding from Dragonfly Biosciences, but would be paid a consultancy fee if I join the Advisory Boorad. My scientific publication support the use of non-THC cannabidinoids, as reflected in this article. I have previously received funding from GW Pharmaceuticals, but I am currently not in receipt of such funding.


University of Reading provides funding as a member of The Conversation UK.

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Epilepsy drugs don’t work well, or at all, for about one-third of people with the condition. Unfortunately, these hard-to-treat epilepsies are associated with an increased risk of premature death.

Anecdotal evidence suggests that cannabis oil may help some of these people control their seizures and potentially save their lives. A small number of studies have shown that adding cannabis oil to existing medication may be effective in devastating, hard-to-treat epilepsy in children and adolescents.

One of those people is 12-year-old Billy Caldwell. Billy was in the news recently after the cannabis oil prescribed for him was confiscated at Heathrow airport by the authorities. Billy’s mother, Charlotte, was attempting to bring the cannabis oil into the UK from Canada, where cannabis oil is legal.

Billy was seizure-free for more than 250 days when taking the oil, but his seizures started again when his cannabis oil was withdrawn. The home secretary, Sajid Javid, was persuaded to intervene and one of the seven bottles of cannabis oil was returned, with a 20-day licence to administer the medicine.

In a similar case, six-year-old Alfie Dingle, who suffers from severe epilepsy, had been successful treated with cannabis oil in the Netherlands. Alfie’s mother, Hannah Deacon, has been campaigning to allow her son to be provided with cannabis oil in the UK.

The government has now also relented in Alfie’s case following the concerns raised around the confiscation and return of Billy Caldwell’s medicine.

Home secretary, Sajid Javid, intervened in Billy Caldwell case and returned a bottle of cannabis oil. EPA/Andy Rain

What the evidence shows

So what do we know about cannabis oil and its effects on epilepsy seizures?

The two main constituents of cannabis oil are THC (tetrahydrocannabinol) and CBD (cannabidiol). Oil containing CBD alone (CBD oil) can be legally bought in the UK without a prescription because it contains only very low quantities of THC. But cannabis oil that contains THC at higher levels (more than 0.3%) is illegal. THC is a schedule 1 drug, that is to say, it is deemed to have no medicinal value.

The reason that Billy’s cannabis oil was seized at Heathrow airport was that it didn’t just contain CBD, it also contained THC at higher levels than legally permitted.

There is good evidence in robust human clinical trials that CBD is of benefit for specific epilepsies, such as Dravet syndrome and Lennox Gastaut syndrome. An advantage for the pharmaceutical industry is that these rare diseases with no cure can be fast-tracked for drug development. On this basis, the US Food and Drug Administration is widely expected to grant a licence for CBD (under the tradename Epidiolex) to treat these epilepsies. If so, Epidiolex is likely to be available in US by late 2018. European approval is likely to follow.

It should be noted that Epidiolex is designed as standardised oral solution of pure plant-derived CBD. It is not the same as the non-standardised, viscous CBD oils that contain varying amounts of CBD and can be purchased in health food shops. There is currently no good evidence that formulations of CBD oil (or indeed cannabis oil) are as effective on epilepsy seizures. Equally, there is no robust evidence – just anecdotal reports – that THC helps reduce epilepsy seizures human.

In [animal studies], THC has weak overall effects in reducing seizures and has also been shown to be a less effective anticonvulsant than CBD. THC, being a psychoactive substance, also has a number of side effects, including the well-known euphoric “high” associated with recreational use – which is a significant disincentive for the pharmaceutical industry to develop a medicine containing this compound.

We now need to decide if we should expand human trials with better defined THC-containing cannabis oil, or if we should focus on CBD. The fact that Epidiolex has progressed towards approval in the US may encourage the latter course. CBD lacks psychoactive effects associated with THC and, in general, is regarded as a safe compound.

If Epidiolex is granted regulatory approval, it will also need to be monitored in a larger number of patients – in what’s known as “phase 4 post-marketing surveillance” – to ensure that it is safe and effective in a broader population. For any cannabis-based product, only large-scale clinical trials can provide definitive answers about effectiveness and safety.

As medicines, not all cannabis products are created equal.

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Keppra or CBD?

Hello! Advice needed ASAP! I’ll give you a quick run down I am 24 years old and recently diagnosed with generalized epilepsy. Being diagnosed is literallu my biggest fear coming true ive always been afraid of having seziures and all these years ive had minor moments of blackkng out but never thought tbey were seziures until this year theyve gotten worse and my EEG showed seziure activity on both sides of my brain. My neuro prescribed me 500mg keppra (generic form) twice a day to start but I am so scared to start it due to everything I’ve read and heard about it and it’s side effects. I’ve done research on CBD and wanted to give it a try but I don’t know how effective it will be. I just want to do something that I know will work, also I had recently been trying to conceive and am worried what my new diagnoses means for TTC. Any advice on ether keppra or CBD would be great. Thanks in advance.


There is a host of

There is a host of information that is well known about Keppra and other seizure medications, but very little on cannabis or CBD. While a few research studies to date look positive for a pharmaceutical grade cannabadiol, we don’t know how it will work in all seizure types. Side effects can occur so it’s important to look into these. Talk to your health care team about options. What’s known about helpfulness, side effects and safety. There are concerns about safety of different products grown. Here is a section on cbd -

I’m just nervous because I’ve

I’m just nervous because I’ve never taken anything so serious and alot of people have said negative things about keppra and have told me to try CBD. I just don’t know which to do

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