cbd dosage for crohn’s

Best CBD Oil For Crohn’s – Top 4 Relieving Products

Crohn’s disease [1] is a chronic, long-term type of inflammatory bowel disease characterized by inflammation in the gastrointestinal tract. It is one of two main types of inflammatory bowel disease along with ulcerative colitis. Both conditions involve an immune reaction against the intestinal tract. Crohn’s disease symptoms [2] are unpleasant and characterized by bloody diarrhea, fever, rectal bleeding, weight loss, and abdominal pain. It is controlled by medications that target the inflammation, including antibiotics, anti-inflammatories, steroids, immune modifiers, or biologic agents. While the exact cause is not understood, it is thought that a combination of genetics, environment, or an overactive immune system may provoke the disease. CBD oil dosage for crohn’s disease is considered a potential cure.

While symptoms may come and go, the onset of symptoms is unpredictable. The treatment goal is the remission of Crohn’s disease symptoms caused by the inflammatory bowel disease process. A special diet is often followed to control the symptoms that include the elimination of alcohol and a restriction of fiber, butter, carbonated beverages, caffeine products, dairy, fatty foods, and corn. Despite the limitations, patients need to maintain a healthy diet because inflammation makes it difficult to absorb nutrients. Avoiding “trigger foods” may help alleviate the inflammatory bowel disease (IBD) symptoms of gas, bloating, and abdominal cramping.

Top 4 Best cbd oil dosage for crohn’s disease (February. 2021)

  • Spruce CBD – Editor’s choice
  • CBD Pure – Best Organic
  • Joy Organics – Best Technology
  • Medterra – Best Price

CBD Oil for Crohn’s

About 15% of inflammatory bowel (IBD) patients report [3] using cannabis to alleviate their symptoms. It appears that medical marijuana has a place in the treatment of IBD. A recent study [4] showed benefits in using 30g marijuana/month that translated into 21 mg THC and 170 mg CBD per day for each of the 173 patients followed. Cannabis decreased the need for other medications. The use of cannabis oil is reported [5] among IBD adolescent patients in another study. Their perceived health benefits from use were on sleep quality, appetite, and nausea.

In the lower digestive tract, endocannabinoids are supposed to protect the gut and reduce motility and inflammation – both of which may lead to the disabling pain associated with ulcerative colitis and Crohn’s disease. Analgesic properties [6] of cannabis products are proposed to be via the TRPV1 endocannabinoid system receptors, and relief is often sought using cannabis oils for the abdominal pain that accompanies the cramping of IBD. The anti-inflammatory effect cannabidiol (CBD) has on tissues should help decrease intestinal inflammation-associated pain. CBD has potent anti-inflammatory activities on pro-inflammatory mediators, making it an ideal choice for the treatment of people with IBD. Read on to find out the best CBD oil dosage for Crohn’s disease.

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Spruce CBD

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The Lineup At A Glance

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Best Organic

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Top 5 Best CBD Oil for Crohn’s Disease

Spruce CBD

Spruce is a family-run CBD brand that offers high-quality, lab-tested, full-spectrum CBD oils made from one of the finest, oldest hemp strains in the United States.

  • 100% natural
  • Family-run
  • Full-spectrum
  • No pesticides
  • High potency available
  • Limited potencies

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Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products and some of the best CBD oils available.

Spruce stands out from the competition in several ways. For instance, it’s a family-run business, which is unusual in the CBD industry.

Its CBD is sourced from a time-tested strain of hemp cultivated in the United States for over two hundred years. The CBD-rich oil is harvested from organically grown hemp from farms in Kentucky and North Carolina.

Spruce is also unique for using a moonshine (alcohol) extraction method to isolate a CBD-rich extract from hemp. Alcohol extraction has proven to be safe and effective.

Spruce’s CBD oils are made with lab-tested hemp extracts, and it provides all of the cannabinoids, terpenes, and other beneficial compounds found in the original plant.

It has a pleasing peppermint taste and comes in 30 ml bottles with two CBD potencies: 25 mg of CBD per ml (750 mg total) and 80 mg of CBD per ml (2400 mg total).

The company carries a wide range of products, including topicals, lotions, balms, tinctures, oils, and capsules.


Medterra manufactures broad-spectrum oil with entourage effects, plus its wide variety of products are all CO2 extracted to yield the best CBD oils for the money.

  • No THC
  • Vegetarian
  • Wide variety of products
  • Limited flavor options

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Medterra is a reputable brand with various CBD products to choose from, including creams, tinctures, edibles, oils, and supplements. Their product line-up includes supplies for your pets.

Their CBD broad-spectrum tincture comes in two potencies, 1000 mg. and 2000 mg. in two flavors plus natural unflavored. CBD oil comes in 500 mg. – 3,000 mg. bottles.

CO2, the gold standard extraction method, can remove THC and impurities from the hemp seed oil to ensure quality CBD oil products.

The wide variety of CBD products all come with a detailed third-party Certificate of Analysis of potency and contaminants. Better yet, it is certified by the U.S. Hemp Authority, which issues guidelines on stringent hemp processing. Third-party testing, as for most products on this list, is conducted on all Medterra products.

MCT is added as a carrier oil and to provide fatty acids. MCT helps the body absorb cannabinoids in the products.


CBDPure is a family-run business that offers organically grown hemp at an affordable price.

  • CO2 Extraction
  • Organic
  • No pesticides
  • Family-run businesses
  • Limited flavor choice

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This organic farm began in 2016 in Colorado with a mission to provide the best CBD products on the market. The farm does not use pesticides or herbicides on its organic ranch in Colorado or its ranch in Washington.

The company does third-party testing with the Certificate of Analysis on its products’ purity for downloading off their website. Their Certificate of Analysis outlines the presence of cannabinoids, terpenes, solvents, pesticides, microbial growth, and heavy metals.

All of their products are minimally processed and grown on family-run farms.

They are affordable and even offer coupons to help defray expenses. We can apply these coupons at check-out for all CBD products.

They offer one natural flavor in three different concentrations of full-spectrum hemp oil, 300 mg, 600 mg, and 900 mg in 30 cc bottles.

The company customer service is highly responsive, with a chat window on the website for immediate assistance if needed. They make sure to meet your requirement.

To prove confidence in their product, CBDPure offers a 100% money-back guarantee. If you are not happy with the products, return them within 90 days for a refund.

Joy Organics

The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten.

  • Free from pesticides
  • No THC products
  • Nanotechnology
  • Family-run
  • Unclear sourcing
  • Not safe for vegans
  • Lack of international shipping

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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids in its oils for a rich entourage effect.. Most CBD oils have a trace of THC in them, but not Joy Organic! Full-spectrum CBD oils are also available with both CBD and less than 0.3% of THC to create the full entourage effect.

The CBD products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these represent standards of quality.

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.

The CBD products come in four flavors, orange, tranquil, natural, and mint. The four flavors come in different potencies, 250, 500, 1000, and 1500 mg per 30 ml bottle.

The oil itself undergoes a process to make it more bioavailable, a nanotechnology

emulsion technique that involves breaking down the molecule into smaller, more digestible components.

CBD Oil Dosage for Crohn’s Disease

The dosage for Crohn’s disease has not been identified in the literature. We have gleaned that too low of a dose is ineffective at treating inflammatory bowel disease (IBD). For example, during eight weeks of treatment with 10 mg cannabidiol (CBD), no significant improvement [7] was noted in 20 patients. Researchers conclude from this study that the dose might have been too low, but they also mention that this was a CBD isolate and do not have the benefits of other cannabinoids for an entourage effect.

In a study of 127 patients undergoing treatment [7] for Crohn’s disease, the dosage used to be effective in intestinal inflammation was 170 mg of CBD in the form of medical cannabis, which also contained THC. This study points to the fact that IBD patients may need a higher dose than 10 mg to exert the necessary anti-inflammatory effects and impact functional symptoms. It also may indicate that using a CBD isolate may perform differently than full extracts from the cannabis sativa plant with all the entourage effects.

In animal models, research has shown positive effects on inflammation in the gut by rectally administering cannabidiol at a dosage of 20 mg/kg. This study indicated a possible role [8] for topical administration directly into the gut mucosa to help decrease inflammation.

In another study on rats, cannabinoids [9] that included THC, at a dose of 10 mg/kg showed a reduction in inflammation and functional symptoms. The dosage curve followed a bell-shaped pattern.

Before trying CBD for gut inflammation, one should seek medical advice, diagnosis, or treatment first as the dosage for this cannabinoid needs tailoring to the individual and drug interactions assessed before administering any dose. Involving the health care system in your decision to use CBD oil will facilitate coordination of treatment.

How Does CBD Oil Help Crohn’s Disease

Cannabinoid receptors 1 and 2, endogenous cannabinoids, and atypical cannabinoids are upregulated in inflammation [10] , and their presence and stimulation aggravate colitis. In contrast, cannabinoid receptor antagonism and cannabinoid receptor-deficient animal models reverse these anti-inflammatory effects. The endocannabinoid system is implicated [11] in gut homeostasis, regulation of intestinal motility, visceral sensation, inflammation, and being recently involved in treating IBD.

Another study demonstrated [12] a role for cannabinoids in reducing intestinal permeability and reducing inflammation and regulation of intestinal bacteria, especially as it related to alcohol use disorders. All of these factors can play a role in symptomatic flare-ups in patients with IBD.

How to Take CBD Oil for Crohn’s Disease

Many people turn to CBD with and without medical advice. Those who may not use CBD may use cannabis to control their pain, weight loss, nausea, and other side-effects of their illness. Cannabis or CBD might play a role in increasing the quality of life for patients with IBD.

You can take CBD in the form of oils, tinctures, capsules, or applied topically in the form of lotion, balms, or creams. For patients with IBD, the best way to take CBD is orally or through the bloodstream by putting tinctures or oils under the tongue or inhaling the oils’ vapors. One might achieve significant health benefits from incorporating the many CBD products on the market into their lifestyle.

Research on CBD and Crohn’s Disease

To date, most of the research has been on cannabis-related products containing a mixture of THC and CBD. The problem is, THC is not legal in every state, and not all people want the “high” effects associated with the use of such products. For this reason, hemp-extracted CBD products are being explored as a treatment option for IBD. The problem with researching CBD oil dosage for crohn’s disease is that the Food and Drug Administration has only patented one CBD drug, which was for epilepsy. It has not been approved for the treatment of this disease.

In a novel approach, a patented enema [13] (all rights reserved) formulation containing CBD has been introduced into the market. The enema protects the intestinal permeability barrier, controls diarrhea, and improves microbiome function. It was explicitly designed with IBD patients in mind after an extensive medical review of the literature.

Still, in light of all the positive data on how CBD might help people with IBD, the medical system seems reluctant to embrace its therapeutic values in health promotion and disease prevention. Many patients could achieve significant health benefits from the use of these products. However, the bottom line is, more research study is in need.

Frequently Asked Questions

Many people turn to CBD for their pain relief and to benefit their overall health. People with IBD have no guidance on dosage for their condition because the FDA has not approved it for use in treating the side-effects associated with IBD. From a review of the studies, it seems that too low of a dose is ineffective at treating symptoms such as weight loss or pain, but the bell-shaped curve present in other dosage studies indicate there might be a “sweet spot” or dosage where symptoms resolve, but a
higher or lower dose will not have the same remission effects. The best thing to ask for medical advice from your healthcare provider.

CBD might help people with IBD manage their health better by decreasing their disease’s symptoms through pain reduction and anti-inflammatory actions. However limited, studies have shown beneficial effects on IBD symptoms in both animals and humans with the use of CBD.

Chemo and Hash plant, both Indica strains, are suitable for Crohn’s disease. Lemon
Jack, Golden Pineapple, and K2 are other strains good for this disorder.

Spruce’s 2,400 mg full-spectrum CBD delivers 80 mg of CBD per 1 milliliter (ml) dose,
which is equivalent to a full dropper.

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Crohn’s & Colitis Foundation. (2020). What Is Crohn’s Disease? Available from:
  2. Crohn’s and Colitis. (2016). WHAT ARE SYMPTOMS OF CROHN’S DISEASE? Available from:‌.
  3. Expert Review of Gastroenterology & Hepatology. (2020). An overview of cannabis based treatment in Crohn’s disease. Available from:‌.
  4. Naftali, T., Bar-Lev Schleider, L., Sklerovsky Benjaminov, F., Lish, I., Konikoff, F.M. and Ringel, Y. (2019). Medical cannabis for inflammatory bowel disease. European Journal of Gastroenterology & Hepatology. Available from:‌
  5. Hoffenberg, E.J., McWilliams, S., Mikulich-Gilbertson, S., Murphy, B., Hoffenberg, A. and Hopfer, C.J. (2019). Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition, 68(3), 348–352. Available from:‌
  6. Barrie, N. and Manolios, N. (2017). The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease. European Journal of Rheumatology, 4(3), 210–218. Available at:
  7. Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M. (2017). Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial. Digestive Diseases and Sciences, 62(6), 1615–1620. Available from:
  8. ‌Schicho, R. and Storr, M. (2012). Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice. Pharmacology, 89(3–4), 149–155. Available at:‌
  9. Jamontt, J., Molleman, A., Pertwee, R. and Parsons, M. (2010). The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation andin vitromotility disturbances in rat colitis. British Journal of Pharmacology, 160(3), 712–723. Available from:‌
  10. Leinwand, K.L., Gerich, M.E., Hoffenberg, E.J. and Collins, C.B. (2017). Manipulation of the Endocannabinoid System in Colitis. Inflammatory Bowel Diseases, 23(2), 192–199. Available at:
  11. Alhouayek, M. and Muccioli, G.G. (2012). The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends in Molecular Medicine, 18(10), 615–625. Available from:‌
  12. Karoly, H.C., Mueller, R.L., Bidwell, L.C. and Hutchison, K.E. (2019). Cannabinoids and the Microbiota–Gut–Brain Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders. Alcoholism: Clinical and Experimental Research, 44(2), 340–353. Available from:
  13. ‌Price, S. (2020). CBD and inflammatory bowel disease: not just a gut feeling. Health Europa. Available from:
About Kathy Shattler, MS, RDN

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.

Having crohn's disease doesn't mean you have to deal with its symptoms. Here are the best CBD oil dosage for crohn's disease in 2021!

CBD for Crohn’s disease

What is Crohn’s Disease

Crohn’s disease is a subcategory of inflammatory bowel disease and is characterized by chronic inflammation of the gastrointestinal tract. Doctors have identified five types of Crohn’s disease. They are:

Ileocolitis – The most common type of Crohn’s disease, ileocolitis affects the small intestine (or ileum) and the colon. Common symptoms include diarrhea, cramping, and considerable weight loss.

Ileitis – This subtype affects only the small intestine or ileum. Common symptoms include diarrhea, cramping, inflammatory abscesses in the lower right side of the abdomen, and considerable weight loss.

Gastroduodenal Crohn’s disease – This subtype affects the stomach and duodenum, which is the first part of the small intestine. Common symptoms include nausea, vomiting, loss of appetite, and weight loss.

Jejunoileitis – This subtype causes areas of inflammation in the jejunum, which is the middle part of the small intestine. Common symptoms include abdominal pain, cramps after meals, and diarrhea.

Crohn’s colitis – This subtype affects only the colon. Common symptoms include rectal bleeding, diarrhea, skin lesions, and joint pain.

Symptoms of Crohn’s Disease

The symptoms of Crohn’s range from mild to severe, differing among patients. They include:

  • Abdominal pain
  • Abdominal cramping
  • Frequent diarrhoea
  • Chronic constipation
  • Rectal bleeding
  • Extreme fatigue
  • Fever
  • Reduced appetite
  • Unexplained weight loss
  • Anal fissures

Crohn’s Disease Medications & Treatment

To date, doctors don’t know what causes Crohn’s and there is currently no known cure. Treatment focuses mainly on symptom management through a combination of lifestyle and dietary changes as well as drug interventions.

Pharmaceutical Interventions
The first step in the treatment of inflammatory bowel diseases such as Crohn’s Disease is for a doctor to prescribe a series of anti-inflammatory drugs. In acute cases, or cases where anti-inflammatories alone do not provide relief, antibiotics are prescribed. Antibiotics can reduce inflammation by targeting harmful bacteria that may play a role in activating the intestinal immune system.

In severe cases where all other interventions have been unsuccessful, surgery is recommended. Nearly half of all Crohn’s disease patients require at least one surgery, during which a surgeon removes the damaged portion of the digestive tract and reconnects the healthy sections. The benefits of surgery are usually only temporary.

Non-Pharmaceutical Interventions
For less severe cases, or as an adjunct to medications, dietary and lifestyle changes are advised for those suffering from Crohn’s disease. It is recommended that sufferers experiencing a “flare up” avoid foods high in insoluble fiber, sugary foods, high-fat foods, alcohol, caffeine, spicy foods and lactose. In addition, it is also helpful to get adequate exercise, stop smoking, and supplement their diet with vitamins and minerals to avoid malnutrition.

CBD in Crohn’s Disease

Research & Scientific Evidence

Several studies regarding cannabidiol (CBD) for treating and managing the symptoms of Crohn’s disease have left scientists feeling optimistic about the efficacy as a potential and promising treatment option. Researchers now believe that CBD may interact at extra-cannabinoid system receptor sites as well as on the gastrointestinal system itself to help reduce inflammation as well as other gut disturbances.

A review study published from 2013 published in Phytotherapy Research highlights the importance of CBD as a non-psychotropic cannabinoid intervention for inflammatory bowel diseases (IBD’s) such as Crohn’s disease.

From the literature, the reviewers concluded that a huge amount of data produced in recent years demonstrates that CBD appears to possess anti-inflammatory, anti-oxidant and anti-apoptotic effects in the central nervous system. Similarly, CBD displays potent anti-inflammatory and immune-modulatory properties, making it a promising therapeutic candidate for inflammatory and pain-associated disorders such as Crohn’s disease. Moreover, CBD also shows to have a beneficial effect of CBD in gut disorders themselves, possessing many protective and anti-oxidant functions, relieving oxidative stress, increasing intestinal motility and selectively inhibiting intestinal hypermotility.

The conclusion was that CBD is a beneficial and immunomodulatory compound that has been widely evidenced in experimental animal models of IBD. According to what they found in the literature, CBD also possesses an “extraordinary range of beneficial effects that may slow the course of the disease, ameliorate symptoms and potentially increase the efficacy of the drugs actually available for the therapy of invalidating gut disorders such as ulcerative colitis or Crohn’s disease.”

Publishing their results in 2017 in the journal Clinical Science, researchers attempted to quantify the anti-inflammatory effects of two cannabinoid drugs, one being CBD. The researchers used ex vivo human tissue obtained from colonic samples of patients with IBD undergoing elective bowel resection. To determine the efficacy of CBD, media concentrations from the cell or colonic cultures were measured for specific proteins to determine the presence of inflammation. They found that CBD shows a significant anti-inflammatory action in experimentally as well as clinically inflamed colon cells while also down regulating pro-inflammatory intracellular pathways.

From the data, they concluded that CBD is well tolerated in humans, has few side effects, and is clinically effective for treating inflammatory bowel disease.

In a randomized control trial published in 2017 in the journal Digestive Diseases and Sciences, the researchers found that, although low-dose CBD is safe, it is not an effective treatment for Crohn’s disease.

In this placebo-controlled trial, 20 patients aged 18–75 years diagnosed a Crohn’s disease were randomized to receive 10 mg of CBD isolate or placebo, administered orally, twice daily. Their Crohn’s disease activity index (CDAI) and laboratory parameters were assessed during 8 weeks of treatment and 2 weeks thereafter. The data showed no statistically significant difference between the CBD and the placebo groups.

The researchers concluded that CBD was safe but had no beneficial effects in patients with moderately active Crohn’s disease. However, they also admitted that the results could be due to the low dose of CBD, the small number of patients in the study and/or a lack of the necessary synergism with other cannabinoids found in full- and broad-spectrum CBD extracts.

Anecdotal Evidence

Anecdotal evidence suggests that CBD as well as medical cannabis can have therapeutically beneficial effects for patients with IBD conditions such as Crohn’s disease. However, the effects of continuous use over long periods of time is rarely discussed.

Although not CBD-specific, an observational study from the European Journal of Gastroenterology and Hepatology set out to investigate the real-life experiences of dose and mode of consumption, side effects and the use of other medications in patients with IBD that use cannabis to control their symptoms.

Significantly, they found that patients experienced significantly fewer symptoms and needed less medications at doses of around 30 g a month. The also noted that there were no negative effects of cannabis use on the patients’ social or occupational status, and in fact, found that employment rates actually increased.

CBD as a complementary treatment for Crohn’s disease

In addition to its anti-inflammatory and anti-oxidant properties that show potential as providing effective symptom relief for patients suffering from Crohn’s disease, CBD can provide benefits as a complementary treatment.

CBD has repeatedly been shown as having the ability to inhibit and control pain while also suppress pain processing and reduce chronic pain by suppressing α3-GlyRs receptors. This can help reduce the abdominal pain and cramping Crohn’s patients often experience.

Similarly, many patients also tend to suffer from anxiety and depression as a side effect of having to deal with the disease. Again, CBD boosts the production of “happy” endocannabinoids such as anandamide (aka bliss molecule) while also binding to the 5-HT1A serotonin receptors implicated in anxiety disorders.

Bottom Line

Crohn’s disease can be painful and, if untreated, debilitating. However, judging from the scientific evidence we have so far, it is clear that the anti-inflammatory and anti-oxidant effects of CBD can help patients suffering from Crohn’s Disease help manage their symptoms, that could eventually result in remission. However, research is still in the early stages. Before using CBD to help treat the symptoms of Crohn’s disease, always consult a medical practitioner first. Not only can CBD interact negatively with other medications, but your physician can monitor dosage, symptom severity and other clinical parameters to ensure that the CBD treatment protocol is both safe and effective.

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In a recent study, Cannabidiol (CBD) was found to reduce permeability in the human colon. According to researchers, “These findings have implications in disorders associated with increased gut permeability, such an inflammatory bowel diseases.”