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Cannabidiol Partially Blocks the Excessive Sleepiness in Hypocretindeficient Rats: Preliminary Data

Affiliations

  • 1 Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.
  • 2 Intercontinental Neuroscience Research Group, Merida, Yucatán, Mexico.
  • 3 Depto. de Neurociencia Cognitiva, División de Neurociencias, Instituto de Fisiología Celular. Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
  • 4 Depto. de Neuropatología Molecular, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
  • 5 Institute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
  • PMID: 31642794
  • DOI: 10.2174/1871527318666191021143300

Cannabidiol Partially Blocks the Excessive Sleepiness in Hypocretindeficient Rats: Preliminary Data

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Authors

Affiliations

  • 1 Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, Mexico.
  • 2 Intercontinental Neuroscience Research Group, Merida, Yucatán, Mexico.
  • 3 Depto. de Neurociencia Cognitiva, División de Neurociencias, Instituto de Fisiología Celular. Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
  • 4 Depto. de Neuropatología Molecular, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
  • 5 Institute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
  • PMID: 31642794
  • DOI: 10.2174/1871527318666191021143300

Abstract

Background: Excessive daytime sleepiness and cataplexy are among the symptoms of narcolepsy, a sleep disorder caused by the loss of hypocretin/orexin (HCRT/OX) neurons placed into the Hypothalamus (LH). Several treatments for managing narcolepsy include diverse drugs to induce alertness, such as antidepressants, amphetamine, or modafinil, etc. Recent evidence has shown that cannabidiol (CBD), a non-psychotropic derived from Cannabis sativa, shows positive therapeutic effects in neurodegenerative disorders, including Parkinson´s disease. Furthermore, CBD provokes alertness and enhances wake-related neurochemicals in laboratory animals. Thus, it is plausible to hypothesize that excessive somnolence observed in narcolepsy might be blocked by CBD.

Objective: Here, we determined whether the systemic injection of CBD (5mg/kg, i.p.) would block the excessive sleepiness in a narcoleptic model.

Methods: To test this idea, the neurotoxin hypocretin-2-saporin (HCRT2/SAP) was bilaterally injected into the LH of rats to eliminate HCRT leading to the establishment of narcoleptic-like behavior. Since excessive somnolence in HCRT2/SAP lesioned rats has been observed during the lights-off period, CBD was administered at the beginning of the dark phase.

Results: Hourly analysis of sleep data showed that CBD blocked the sleepiness during the lights-off period across 7h post-injection in lesioned rats.

Conclusion: Taking together, these preliminary findings suggest that CBD might prevent sleepiness in narcolepsy.

Keywords: Cannabidiol; hypocretin-deficient rats; lateral hypothalamus; narcolepsy; neurodegenerative disorder; rapid eye movement sleep..

Taking together, these preliminary findings suggest that CBD might prevent sleepiness in narcolepsy.

How can CBD oil assist people with Narcolepsy?

The symptoms of narcolepsy can be substantially reduced when people make use of cannabis oil. One of the chemicals in cannabis is known as THC or Tetrahydrocannabinol and it is now a well-known fact that THC has the ability to assist people suffering from sleeping disorders. Many people are skeptical about THC because it is known to be a psychoactive substance which is banned in most parts of the world. This does not change the fact that it is also a very powerful alternative medication which will do no harm when taken in the correct dose.

A substantial amount of research has already been done which has indicated that the problems associated with insomnia can be addressed by making use of THC. When making use of THC very few sleepless hours is spent every night. Most people are able to sleep through something which they cannot do without THC. Even those suffering from nightmares can benefit from cannabinoids. It is also helps people with a post-traumatic sleep disorder. With most sleeping disorders THC has been found to be highly effective. The question is what can it do for those suffering from narcolepsy where people actually have to stay awake.

Cannabis oil seems to be the answer

CBD infused cannabis oil has proven itself to be a very remarkable product. It has been found that CBD is a cannabinoid which is able to calm people. At the same time, it is able to keep people alert. It is one of the primary cannabinoids which is extracted from cannabis. This substance has now been legalized in many parts of the world. This is because of its indisputable and unique medical properties.

Any person who consumes small doses of CBD will experience a higher state of alertness which is exactly what someone with narcolepsy will require. It will be important for people with this condition to ensure that they take only enough to provide them with the necessary benefits. It has been seen in studies that CBD can help to significantly improve the consistency of sleeping cycles. This results in a situation where a person is able to feel alert for many hours each day.

CBD and the body’s own systems

The interesting thing is that CBD is able to cooperate with systems in the body such as the endocannabinoid receptors, as well as several proteins and some chemicals in the brain. It has been discovered that this can result in beneficial changes in the way in which hormones, neurotransmitters and other cells in the body and brain function. This simply means that CBD can effectively reset the daytime alertness patterns of the body. It can also help to effectively regulate emotional responses.

CBD can also assist with things such as the way in which the body recognizes pain, seizures, and inflammation. The good news for narcolepsy patients is that making use of CBD hemp oil can do a lot to help them to become more alert and also to have a safer existence during daylight hours. It could be beneficial to always have a small amount of CBD oil or ointment with you at all times. When tiredness is experienced you can simply take some CBD to get you through a difficult time.

Narcolepsy and the Healing Power of CBD Cannabis Oil – It has been found that CBD is a cannabinoid which is able to calm people